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CYCLOCELL Project : cyclodextrin functionalized nanocellulose for tissue engineering applications

Offre de thèse - Glyco@Alps

Mis à jour le 31 mai 2018
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Nanocelluloses are promising materials within the medical field; for wound healing, as scaffolds in tissue engineering and for drug delivery. For some years research on utilization of nanocellulose extracted from wood (i.e. wood based cellulose nanofibrils (CNF)) for medical applications has been conducted at RISE PFI / NTNU and LGP2 together with various collaborators. Important fundamental studies have been done, for example cytotoxicity studies have confirmed that wood-based nanocellulose basically are safe, cell-friendly porous structures has been constructed, and control of mechanical properties of CNF-based structures has been demonstrated. In tissue engineering, the scaffold should stimulate cells to proliferate and form tissue. This requires a delicate balance between properties such as strength, morphology and chemistry. Fundamental properties of structures made from wood-based CNF, substrates combining CNF and other components (e.g. biopolymers, ligands with specific functionality, drugs) and the interplay between cells and the different substrates are currently studied. Such networks can be functionalized with cyclodextrin with the purpose to obtain controlled release of growth factor molecules or specific proteins.

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Rédigé par Anne Pandolfi

mise à jour le 31 mai 2018

Grenoble INP Institut d'ingénierie Univ. Grenoble Alpes